Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry, and Light Scattering

  • Mingrui Zhao
  • Hongtao Ma
  • Samuel Harris
  • Theodore H. Schwartz
Protocol
Part of the Neuromethods book series (NM, volume 88)

Abstract

Advances in functional imaging techniques including fMRI, PET, and SPECT have improved our understanding of the relationship between brain activity and brain energy supply. Neurovascular and neurometabolic coupling are critical to supply the energy demands of brain tissue during both normal physiological function and pathological conditions. With the use of multi-spectral imaging techniques, one can simultaneously measure changes in cerebral blood volume, oxyhemoglobin, deoxyhemoglobin, light scattering, and local metabolism during epilepsy.

Key words

Neurovascular coupling Epilepsy Intrinsic optical imaging Autofluorescence Brain activity map 

Notes

Acknowledgements

This work was supported by the NINDS RO1 NS49482 (T.H.S), CURE Taking Flight Award (H.M.), the Clinical and Translational Science Center (CTSC) Grant UL1 RR 024996 Pilot Grant (M.Z), and the Cornell University Ithaca-WCMC seed grant (M.Z.). We thank Dr. Yevgeniy B. Sirotin for help with LED setup and AFI analysis.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Mingrui Zhao
    • 1
  • Hongtao Ma
    • 1
  • Samuel Harris
    • 2
    • 3
  • Theodore H. Schwartz
    • 4
  1. 1.Department of Neurological SurgeryBrain and Mind Research Institute, Weill Cornell Medical CollegeNew YorkUSA
  2. 2.Department of PsychologyThe University of SheffieldSheffieldUK
  3. 3.Department of Neurological SurgeryWeill Cornell Medical CollegeNew YorkUSA
  4. 4.Department of Neurological SurgeryBrain and Mind Research Institute, Weill Cornell Medical College, New York Presbyterian HospitalNew YorkUSA

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