Genome-Scale Metabolic Models of Yeast, Methods for Their Reconstruction, and Other Applications
Here, we present the concept of genome-scale metabolic models and some of their applications in metabolic engineering of yeast and in the analysis of gene expression data. The yeast species for which there are available genome-scale metabolic models are reviewed, as well as the methods for the reconstruction of genome-scale metabolic models for new species. Some commonly used algorithms for metabolic engineering and data integration are described.
Key wordsMetabolic engineering Gene expression Metabolic networks Data integration