Animal Models to Evaluate Bacterial Biofilm Development

  • Kim Thomsen
  • Hannah Trøstrup
  • Claus MoserEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1147)


Medical biofilms have attracted substantial attention especially in the past decade. Animal models are contributing significantly to understand the pathogenesis of medical biofilms. In addition, animal models are an essential tool in testing the hypothesis generated from clinical observations in patients and preclinical testing of agents showing in vitro antibiofilm effect. Here, we describe three animal models — two non-foreign body Pseudomonas aeruginosa biofilm models and a foreign body Staphylococcus aureus model.

Key words

Chronic lung infection Chronic wound infection Pseudomonas aeruginosa Staphylococcus aureus Animal models 



Mark Shirtliff contributed fully as a co-author for this chapter and should be regarded as such.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Clinical MicrobiologyRigshospitalet, Copenhagen University HospitalCopenhagenDenmark
  2. 2.Department of International Health, Immunology and MicrobiologyRigshospitalet and Copenhagen UniversityCopenhagenDenmark

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