Abstract
Drug and cell delivery systems could be modulated to serve as instructive microenvironments in regenerative medicine. Towards this end, several synthetic biomaterials have been developed to mimic the natural extracellular matrix (ECM) for therapeutic use. These include synthetic polymers, decellularized ECM, self-assembling polymers, and cell-responsive hydrogels with varied applications. Here, we describe the development of a self-assembling peptide hydrogel and its potential use as a cell and growth factor delivery vehicle to the infarcted heart in a rodent model of myocardial infarction.
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Acknowledgements
This work was supported by grant HL094527 to M.E.D. from the National Heart, Lung, and Blood Institute, an American Heart Association predoctoral fellowship 11PRE7840078 to A.V.B.
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Boopathy, A.V., Davis, M.E. (2014). Self-Assembling Peptide-Based Delivery of Therapeutics for Myocardial Infarction. In: Jain, K. (eds) Drug Delivery System. Methods in Molecular Biology, vol 1141. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0363-4_10
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DOI: https://doi.org/10.1007/978-1-4939-0363-4_10
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