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Imageable Clinically Relevant Mouse Models of Metastasis

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Metastasis Research Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1070))

Abstract

In the past 10 years, we have developed a new approach to the development of a clinically accurate rodent model for human cancer based on our invention of surgical orthotopic implantation (SOI). The SOI models have been described in approx. 70 publications and in 4 patents.*SOI allows human tumors of all the major types of human cancer to reproduce clinical like tumor growth and metastasis in the transplanted rodents. The major features of the SOI models are reviewed here and also compared to transgenic mouse models of cancer.

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Authors and Affiliations

  1. AntiCancer, Inc., San Diego, CA, USA

    Robert M. Hoffman

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  1. Robert M. Hoffman
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  1. Molecular and Applied Biosciences, University of Westminster School of Life Sciences, London, United Kingdom

    Miriam Dwek

  2. Morphologie, Universitätsklinikum Hamburg Inst. Anatomie und Experimentelle, Hamburg, Germany

    Udo Schumacher

  3. Oxford Brookes University School of Life Sciences, Oxford, United Kingdom

    Susan A. Brooks

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Hoffman, R.M. (2014). Imageable Clinically Relevant Mouse Models of Metastasis. In: Dwek, M., Schumacher, U., Brooks, S. (eds) Metastasis Research Protocols. Methods in Molecular Biology, vol 1070. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8244-4_11

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  • DOI: https://doi.org/10.1007/978-1-4614-8244-4_11

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