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Imageable Clinically Relevant Mouse Models of Metastasis

Protocol
First Online:
Part of the Methods in Molecular Biology book series (MIMB, volume 1070)

Abstract

In the past 10 years, we have developed a new approach to the development of a clinically accurate rodent model for human cancer based on our invention of surgical orthotopic implantation (SOI). The SOI models have been described in approx. 70 publications and in 4 patents.*SOI allows human tumors of all the major types of human cancer to reproduce clinical like tumor growth and metastasis in the transplanted rodents. The major features of the SOI models are reviewed here and also compared to transgenic mouse models of cancer.

Key words

Metastasis Orthotopic Nude mice GFP Imaging 
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© Springer Science+Business Media, New York 2014

Authors and Affiliations

  1. 1.AntiCancer, Inc.San DiegoUSA

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