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An Introduction to Chemogenomics

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Chemogenomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2706))

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Abstract

Chemogenomics is an innovative approach in chemical biology that synergizes combinatorial chemistry and genomic and proteomic biology to systematically study the response of a biological system to a set of compounds, which can aid the identification and validation of biological targets as well as biologically active small-molecule agents responsible for a phenotypic outcome. Central to this strategy is a collection of chemically diverse compounds, a so-called chemogenomics library. Selection and annotation of vastly available chemogenomic compound candidates for an inclusion in such set present a challenge, but optimal compound selection is critical for success of chemogenomics. The library can be used in a wide variety of research applications from biological mechanism deconvolution to drug discovery. However, phenotypic screening methods are typically required to be high-throughput and equipped with a systematic analysis of complex biological–chemical interactions. This chapter provides a general outline to the chemogenomics approach, including concept and critical steps in all stages of this innovative chemical biology strategy.

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Author information

Authors and Affiliations

  1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany

    Apirat Chaikuad & Daniel Merk

  2. Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany

    Daniel Merk

Authors
  1. Apirat Chaikuad
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  2. Daniel Merk
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Corresponding author

Correspondence to Daniel Merk .

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Editors and Affiliations

  1. Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany

    Daniel Merk

  2. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany

    Apirat Chaikuad

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Chaikuad, A., Merk, D. (2023). An Introduction to Chemogenomics. In: Merk, D., Chaikuad, A. (eds) Chemogenomics. Methods in Molecular Biology, vol 2706. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3397-7_1

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  • DOI: https://doi.org/10.1007/978-1-0716-3397-7_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3396-0

  • Online ISBN: 978-1-0716-3397-7

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