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Mouse Models of Mucormycosis

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Antifungal Immunity

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2667))

Abstract

Animal models have been crucial in understanding the pathogenesis and developing novel therapeutic approaches for fungal infections in general. This is especially true for mucormycosis, which has a low incidence but is often fatal or debilitating. Mucormycoses are caused by different species, via different routes of infections, and in patients differing in their underlying diseases and risk factors. Consequently, clinically relevant animal models use different types of immunosuppression and infection routes.

This chapter describes how to induce different types of immunosuppression (high dose corticosteroids and induction of leukopenia, respectively) or diabetic ketoacidosis as underlying risk factors for mucormycosis. Furthermore, it provides details on how to perform intranasal application to establish pulmonary infection. Finally, some clinical parameters that can be used for developing scoring systems and define humane endpoints in mice are discussed.

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Author information

Authors and Affiliations

  1. Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany

    Ilse D. Jacobsen

  2. Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany

    Ilse D. Jacobsen

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  1. Ilse D. Jacobsen
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Correspondence to Ilse D. Jacobsen .

Editor information

Editors and Affiliations

  1. Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Rebecca A. Drummond

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Jacobsen, I.D. (2023). Mouse Models of Mucormycosis. In: Drummond, R.A. (eds) Antifungal Immunity. Methods in Molecular Biology, vol 2667. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3199-7_14

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  • DOI: https://doi.org/10.1007/978-1-0716-3199-7_14

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3198-0

  • Online ISBN: 978-1-0716-3199-7

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