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Homology Modeling of the G Protein-Coupled Receptors

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Homology Modeling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2627))

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Abstract

G protein-coupled receptors (GPCRs) are therapeutically important family of membrane proteins. Despite growing number of experimental structures available for GPCRs, homology modeling remains a relevant method for studying these receptors and for discovering new ligands for them. Here we describe the state-of-the-art methods for modeling GPCRs, starting from template selection, through fine-tuning sequence alignment to model refinement.

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Author information

Author notes

  1. Stefan Mordalski and Tomasz Kościółek contributed equally.

Authors and Affiliations

  1. Department of Medicinal Chemistry, Maj Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

    Stefan Mordalski

  2. Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland

    Tomasz Kościółek

Authors
  1. Stefan Mordalski
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  2. Tomasz Kościółek
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Corresponding author

Correspondence to Stefan Mordalski .

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Editors and Affiliations

  1. Faculty of Chemistry, University of Warsaw, Warsaw, Poland

    Sławomir Filipek

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Mordalski, S., Kościółek, T. (2023). Homology Modeling of the G Protein-Coupled Receptors. In: Filipek, S. (eds) Homology Modeling. Methods in Molecular Biology, vol 2627. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2974-1_9

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  • DOI: https://doi.org/10.1007/978-1-0716-2974-1_9

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2973-4

  • Online ISBN: 978-1-0716-2974-1

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