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The Vast Utility of Drosophila Oogenesis

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Drosophila Oogenesis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2626))

Abstract

In this chapter, we highlight examples of the diverse array of developmental, cellular, and biochemical insights that can be gained by using Drosophila melanogaster oogenesis as a model tissue. We begin with an overview of ovary development and adult oogenesis. Then we summarize how the adult Drosophila ovary continues to advance our understanding of stem cells, cell cycle, cell migration, cytoplasmic streaming, nurse cell dumping, and cell death. We also review emerging areas of study, including the roles of lipid droplets, ribosomes, and nuclear actin in egg development. Finally, we conclude by discussing the growing conservation of processes and signaling pathways that regulate oogenesis and female reproduction from flies to humans.

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Acknowledgments

We thank the Tootle lab for helpful discussions and careful review of the manuscript. The following sources provided funding for this project: National Institutes of Health R35 GM144057 (T.L.T.) and National Science Foundation MCB 2017797 (T.L.T.). M.S.G. is supported by NIH T32 CA078586 Free Radical and Radiation Biology, University of Iowa.

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  1. Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Michelle S. Giedt & Tina L. Tootle

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  1. Michelle S. Giedt
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  2. Tina L. Tootle
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Correspondence to Tina L. Tootle .

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  1. Department of Anatomy & Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Michelle S. Giedt

  2. Department of Anatomy & Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Tina L. Tootle

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Giedt, M.S., Tootle, T.L. (2023). The Vast Utility of Drosophila Oogenesis. In: Giedt, M.S., Tootle, T.L. (eds) Drosophila Oogenesis. Methods in Molecular Biology, vol 2626. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2970-3_1

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