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Chemical Synthesis and Molecular Interaction Analysis of α-Galactosyl Ceramide Derivatives as CD1d Ligands

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Glycolipids

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2613))

Abstract

CD1d is a non-classical major histocompatibility complex (MHC) protein, responsible for lipid antigen presentation, which presents lipids to natural killer T (NKT) cells. Various CD1d lipid ligands have been reported, including microbial and endogenous glycolipids/phospholipids. Among them, an α-galactosylceramide (α-GalCer), a representative CD1d ligand, is one of the most potent ligands and its derivatives have been developed. In this chapter, the chemistry of α-GalCer and its derivatives are described with an emphasis on their chemical syntheses and molecular interaction analysis with CD1d are described.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan

    Kazunari Ueki, Kodai Sueyoshi & Yukari Fujimoto

  2. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Shinsuke Inuki

Authors
  1. Kazunari Ueki
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  2. Kodai Sueyoshi
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  3. Shinsuke Inuki
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  4. Yukari Fujimoto
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Corresponding author

Correspondence to Yukari Fujimoto .

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Editors and Affiliations

  1. Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan

    Kazuya Kabayama

  2. Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Jin-ichi Inokuchi

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Ueki, K., Sueyoshi, K., Inuki, S., Fujimoto, Y. (2023). Chemical Synthesis and Molecular Interaction Analysis of α-Galactosyl Ceramide Derivatives as CD1d Ligands. In: Kabayama, K., Inokuchi, Ji. (eds) Glycolipids. Methods in Molecular Biology, vol 2613. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2910-9_2

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  • DOI: https://doi.org/10.1007/978-1-0716-2910-9_2

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2909-3

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