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Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

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T-Cell Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2580))

Abstract

While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

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Authors and Affiliations

  1. Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA

    Alejandra V. Contreras & David L. Wiest

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  1. Alejandra V. Contreras
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  2. David L. Wiest
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Correspondence to David L. Wiest .

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Editors and Affiliations

  1. Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Remy Bosselut

  2. Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Melanie S. Vacchio

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Contreras, A.V., Wiest, D.L. (2023). Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles. In: Bosselut, R., Vacchio, M.S. (eds) T-Cell Development. Methods in Molecular Biology, vol 2580. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2740-2_4

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  • DOI: https://doi.org/10.1007/978-1-0716-2740-2_4

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