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Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s Disease

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Alzheimer’s Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2561))

Abstract

Alzheimer’s disease (AD) is a common neurodegenerative disorder and a mechanistically complex disease. For the last decade, human models of AD using induced pluripotent stem cells (iPSCs) have emerged as a powerful way to understand disease pathogenesis in relevant human cell types. In this review, we summarize the state of the field and how this technology can apply to studies of both familial and sporadic studies of AD. We discuss patient-derived iPSCs, genome editing, differentiation of neural cell types, and three-dimensional organoids, and speculate on the future of this type of work for increasing our understanding of, and improving therapeutic development for, this devastating disease.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA

    Jessica E. Young

  2. Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA

    Jessica E. Young

  3. Department of Cellular and Molecular Medicine, Department of Neurosciences, UC San Diego, La Jolla, CA, USA

    Lawrence S. B. Goldstein

  4. Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA

    Lawrence S. B. Goldstein

Authors
  1. Jessica E. Young
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  2. Lawrence S. B. Goldstein
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Correspondence to Jessica E. Young .

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Editors and Affiliations

  1. Translational Neuroscience Initiative, Neuroscience Drug Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

    Jerold Chun

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Young, J.E., Goldstein, L.S.B. (2023). Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s Disease. In: Chun, J. (eds) Alzheimer’s Disease. Methods in Molecular Biology, vol 2561. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2655-9_6

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  • DOI: https://doi.org/10.1007/978-1-0716-2655-9_6

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2654-2

  • Online ISBN: 978-1-0716-2655-9

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