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Use of the Medmont Dark-Adapted Chromatic Perimeter for Assessing Rod Function in Retinitis Pigmentosa

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Retinitis Pigmentosa

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2560))

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Abstract

Medmont Dark-Adapted Chromatic (DAC) Perimeter enables efficient and quantifiable evaluation of rod-mediated (scotopic) vision. DAC tests rod function at multiple retinal locations, creating a topographical map of rod-mediated vision. These dynamic rod responses can be used as a functional marker to monitor disease progression and functional alterations in inherited retinal dystrophies, such as retinitis pigmentosa, Stargardt disease, cone-rod dystrophy, and choroideremia. In this chapter, we describe a protocol for the operation and analysis of the Medmont DAC in monitoring and assessing various retinal disorders.

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References

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Author information

Authors and Affiliations

  1. Steven and Alexandra Cohen Children’s Medical Center of New York, Queens, NY, USA

    Yan Nuzbrokh

  2. Warren Alpert Medical School at Brown University, Providence, RI, USA

    Sara D. Ragi

  3. Departments of Ophthalmology, Pathology & Cell Biology, Graduate Programs in Nutritional & Metabolic Biology and Neurobiology & Behavior, Columbia Stem Cell Initiative, New York, NY, USA

    Stephen H. Tsang

Authors
  1. Yan Nuzbrokh
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  2. Sara D. Ragi
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  3. Stephen H. Tsang
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Corresponding author

Correspondence to Stephen H. Tsang .

Editor information

Editors and Affiliations

  1. Departments of Ophthalmology, Pathology & Cell Biology Graduate Programs in Nutritional & Metabolic Biology and Neurobiology & Behavior, Columbia Stem Cell Initiative, New York, NY, USA

    Stephen H. Tsang

  2. Department of Ophthalmology, Columbia University Medical Center, New York, NY, USA

    Peter M.J. Quinn

Ethics declarations

Stephen H. Tsang receives financial support from Abeona Therapeutics, Inc and Emendo. He is also the founder of Rejuvitas and is on the scientific and clinical advisory board for Nanoscope Therapeutics.

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Nuzbrokh, Y., Ragi, S.D., Tsang, S.H. (2023). Use of the Medmont Dark-Adapted Chromatic Perimeter for Assessing Rod Function in Retinitis Pigmentosa. In: Tsang, S.H., Quinn, P.M. (eds) Retinitis Pigmentosa. Methods in Molecular Biology, vol 2560. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2651-1_17

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  • DOI: https://doi.org/10.1007/978-1-0716-2651-1_17

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2650-4

  • Online ISBN: 978-1-0716-2651-1

  • eBook Packages: Springer Protocols

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