Abstract
Inherited retinal diseases (IRDs), including retinitis pigmentosa, have devastating consequences for the visual function of affected individuals. Chief among these are a gradual loss of visual field, visual acuity, and night vision (otherwise known as nyctalopia). These changes often occur slowly, over a course of decades. Objective modalities for assessing these many aspects of visual function are crucial, not only to the monitoring of disease progression but, in recent years, also to evaluating the efficacy or lack thereof of new therapeutic interventions in the setting of clinical trials. This chapter will provide descriptions of these valuable assessment modalities, alongside discussions of their advantages and limitations in the context of serving those afflicted by IRDs.
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Levenson JH, Kozarsky A (1990) Visual acuity. In: Walker HK, Hall WD, Hurst JW (eds) Clinical methods: the history, physical, and laboratory examinations, 3rd edn. Butterworths, Boston. Chapter 115. Available from: https://www.ncbi.nlm.nih.gov/books/NBK219/
Roberta A (1988) Pagon, retinitis pigmentosa. Surv Ophthalmol 33(3):137–177. ISSN 0039-6257, https://doi.org/10.1016/0039-6257(88)90085-9
Spark Therapeutics Briefing Document: October 12, 2017
Lange C, Feltgen N, Junker B, Schulze-Bonsel K, Bach M (2009) Resolving the clinical acuity categories “hand motion” and “counting fingers” using the Freiburg Visual Acuity Test (FrACT). Graefes Arch Clin Exp Ophthalmol 247(1):137–142
Levenson JH, Kozarsky A (1990) Visual fields. In: Walker HK, Hall WD, Hurst JW (eds) Clinical methods: the history, physical, and laboratory examinations, 3rd edn. Butterworths, Boston. Chapter 116. Available from: https://www.ncbi.nlm.nih.gov/books/NBK219/
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on Public Health Approaches to Reduce Vision Impairment and Promote Eye Health (2016) In: Welp A, Woodbury RB, McCoy MA et al (eds) Making eye health a population health imperative. National Academies Press (US), Washington, DC
National Eye Institute (August 2000) Version 2000 The National Eye Institute 25-item visual function questionnaire. https://nei.nih.gov/sites/default/files/nei-pdfs/manual_cm2000.pdf
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Stephen H. Tsang receives financial support from Abeona Therapeutics, Inc and Emendo. He is also the founder of Rejuvitas and is on the scientific and clinical advisory board for Nanoscope Therapeutics.
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Chumdermpadetsuk, R., Ragi, S.D., Tsang, S.H. (2023). Visual Function Tests. In: Tsang, S.H., Quinn, P.M. (eds) Retinitis Pigmentosa. Methods in Molecular Biology, vol 2560. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2651-1_12
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DOI: https://doi.org/10.1007/978-1-0716-2651-1_12
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