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SARS-CoV-2 pp 183–196Cite as

Detection of SARS-CoV-2 by Mass Spectrometry

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Part of the Methods in Molecular Biology book series (MIMB,volume 2452)

Abstract

Amplification of viral ribonucleic acid by real-time reverse transcriptase polymerase chain reaction is the gold standard to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, alternative reliable, fast, and cost-effective methods for the detection of SARS-CoV-2 are still needed. In this chapter, the mass spectrometry–based detection of amplified polymerase chain reaction products of SARS-CoV-2 genes from oral or nasopharyngeal swabs is described. The respective SARS-CoV-2 test has previously been shown to meet standard quality criteria and was therefore approved by the authorities in Europe and the USA.

Key words

  • Mass Spectrometry
  • MassARRAY
  • SARS-CoV-2
  • COVID-19

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Correspondence to Mark Kriegsmann .

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Wandernoth, P., Kriegsmann, K., Kriegsmann, J., Kriegsmann, M. (2022). Detection of SARS-CoV-2 by Mass Spectrometry. In: Chu, J.J.H., Ahidjo, B.A., Mok, C.K. (eds) SARS-CoV-2. Methods in Molecular Biology, vol 2452. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2111-0_12

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  • DOI: https://doi.org/10.1007/978-1-0716-2111-0_12

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2110-3

  • Online ISBN: 978-1-0716-2111-0

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