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In Silico Methods for Predicting Drug Toxicity pp 133–146Cite as

Emerging Bioinformatics Methods and Resources in Drug Toxicology

Part of the Methods in Molecular Biology book series (MIMB,volume 2425)

Abstract

Assessing the drug safety at an early stage of a drug discovery program is a critical issue. With the recent advances in molecular biology and genomic, massive amounts of generated and accumulated data by advanced experimental technologies such as RNA sequencing or proteomics start to be at the disposal of the scientific community. Innovative and adequate bioinformatic methods, tools, and protocols are required to analyze properly these diverse and extensive data sources with the aim to identify key features that are related to toxicity observations. Furthermore, the assessment of drug safety can be performed across multiple scales of complexity from molecular, cellular to phenotypic levels; therefore, the application of network science contributes to a better interpretation of the drug’s exposure effect on human health. Here, we review databases containing toxicogenomics and chemical-phenotype information, as well as appropriated bioinformatics approaches that are currently used to analyze such data. Extension to others methods such as dose–responses, time-dependent processes, and text mining is also presented giving an overview of suitable tools available for a best practice of drug safety analysis.

Key words

  • Drug safety
  • Bioinformatics
  • Network biology
  • RNA sequencing
  • Toxicology
  • Text mining

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Acknowledgments

This work was supported by the University of Paris and INSERM.

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Authors and Affiliations

  1. Université de Paris, Inserm UMR S-1124, Paris, France

    Karine Audouze

  2. Université de Paris, Inserm U1133, CNRS UMR 8251, Paris, France

    Olivier Taboureau

Authors
  1. Karine Audouze
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  2. Olivier Taboureau
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Corresponding author

Correspondence to Olivier Taboureau .

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Editors and Affiliations

  1. Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

    Dr. Emilio Benfenati

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Audouze, K., Taboureau, O. (2022). Emerging Bioinformatics Methods and Resources in Drug Toxicology. In: Benfenati, E. (eds) In Silico Methods for Predicting Drug Toxicity. Methods in Molecular Biology, vol 2425. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1960-5_6

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  • DOI: https://doi.org/10.1007/978-1-0716-1960-5_6

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