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Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors

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Synaptic Vesicles

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2417))

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Abstract

Herein we describe the detailed synthesis of the dynamin inhibitors Phthaladyn-29 and Napthaladyn-10, and their chemical scaffold matched partner inactive compounds. Combined with the assay data provided, this allows the interrogation of dynamin in vitro and potentially in vivo.

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Author information

Authors and Affiliations

  1. Chemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia

    Cecilia C. Russell, Kate L. Prichard, Nicholas S. O’Brien, Adam McCluskey & Jennifer R. Baker

  2. Cell Signaling Unit, Children’s Medical Research Institute, The University of Sydney, Sydney, NSW, Australia

    Phillip J. Robinson

Authors
  1. Cecilia C. Russell
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  2. Kate L. Prichard
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  3. Nicholas S. O’Brien
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  4. Adam McCluskey
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  5. Phillip J. Robinson
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  6. Jennifer R. Baker
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Corresponding author

Correspondence to Jennifer R. Baker .

Editor information

Editors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Bayern, Germany

    Jana Dahlmanns

  2. Institute for Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen, Germany

    Marc Dahlmanns

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© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Russell, C.C., Prichard, K.L., O’Brien, N.S., McCluskey, A., Robinson, P.J., Baker, J.R. (2022). Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors. In: Dahlmanns, J., Dahlmanns, M. (eds) Synaptic Vesicles. Methods in Molecular Biology, vol 2417. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1916-2_18

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  • DOI: https://doi.org/10.1007/978-1-0716-1916-2_18

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1915-5

  • Online ISBN: 978-1-0716-1916-2

  • eBook Packages: Springer Protocols

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