Abstract
Blood vessels in the body are multiphasic organs with microenvironmental niches specific to the cells that inhabit each section. Electrospinning is a fabrication technique used to produce nano- to microfibrous architectures capable of mimicking native extracellular matrix structure. Likewise, polycitrate elastomers are favorable luminal materials for vascular applications because of their hemocompatibility and mechanical properties. Here we describe the procedure for fabricating a biphasic polycitrate elastomer, collagen, and elastin electrospun composite to spatially tailor both composition and architecture for recapitulating the intimal and medial layers of the blood vessel in a vascular graft.
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Acknowledgments
This work was funded by a US Army Medical Research and Material Command Grant (W81XWH-15-1-0066) awarded to J.A. Opinions, interpretations, conclusions, and recommendations in this work are those of the authors and are not necessarily endorsed by the Department of Defense.
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James, B.D., Allen, J.B. (2022). Engineering Vascular Grafts with Multiphase Structures. In: Zhao, F., Leong, K.W. (eds) Vascular Tissue Engineering. Methods in Molecular Biology, vol 2375. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1708-3_10
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DOI: https://doi.org/10.1007/978-1-0716-1708-3_10
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Publisher Name: Humana, New York, NY
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Online ISBN: 978-1-0716-1708-3
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