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Peptide Macrocycles pp 43–61Cite as

Three Methods for the Solution Phase Synthesis of Cyclic Peptides

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Part of the Methods in Molecular Biology book series (MIMB,volume 2371)

Abstract

Cyclic peptides, which often exhibit interesting biological properties, can be obtained by macrolactamization of adequately protected linear peptide chains. Because of the remarkable biological properties, methods for the efficient cyclization of peptides are of high interest. We herein describe three different protocols for the cyclization of peptides and depsipeptides via amide bond formation. These methods can, in principal, be applied to any linear peptide chain.

Key words

  • Cyclopeptides
  • Cyclodepsipeptides
  • Macrocyclization of peptides
  • Macrolactamization
  • Peptide coupling

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  • DOI: 10.1007/978-1-0716-1689-5_4
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Acknowledgments

This work was supported by Saarland University.

Author information

Authors and Affiliations

  1. Organic Chemistry, Saarland University, Saarbrücken, Germany

    Angelika Ullrich, Lukas Junk & Uli Kazmaier

Authors
  1. Angelika Ullrich
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  2. Lukas Junk
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  3. Uli Kazmaier
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Corresponding author

Correspondence to Angelika Ullrich .

Editor information

Editors and Affiliations

  1. DEVCOM Army Research Lab, Adelphi, MD, USA

    Ph.D. Matthew B. Coppock

  2. DEVCOM Army Research Lab, Adelphi, MD, USA

    Alexander J. Winton

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Ullrich, A., Junk, L., Kazmaier, U. (2022). Three Methods for the Solution Phase Synthesis of Cyclic Peptides. In: Coppock, M.B., Winton, A.J. (eds) Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1689-5_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1689-5_4

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