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Designing Efficient Cascade Reactions in Drug Discovery

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Green Chemistry in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

This chapter focuses on the exploration and application of cascade reactions in the total synthesis of both biologically active natural products and their analogues and synthetic substances for drug discovery. The high synthetic efficiency of such processes enables the facile and rapid construction of bioactive molecules and furthermore streamlines the study of structure-activity relationships to accelerate the identification of potential drug-like compounds for further biological evaluation. In addition, the power of cascade strategies is also demonstrated in the pilot plant-scale synthesis of highly valued, structurally complex drugs and drug candidates.

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Acknowledgments

The financial support from the NSF (CHE-1057569) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, NM, USA

    Chenguang Yu, He Huang, Chunquan Sheng & Wei Wang

  2. Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China

    Chunquan Sheng

  3. College of Pharmacy, University of Arizona, Tucson, AZ, USA

    Wei Wang

Authors
  1. Chenguang Yu
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  2. He Huang
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  3. Chunquan Sheng
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  4. Wei Wang
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Corresponding author

Correspondence to Wei Wang .

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Editors and Affiliations

  1. World Wide Medicinal Chemistry, Pfizer Inc., San Diego, CA, USA

    Paul F. Richardson

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Yu, C., Huang, H., Sheng, C., Wang, W. (2022). Designing Efficient Cascade Reactions in Drug Discovery. In: Richardson, P.F. (eds) Green Chemistry in Drug Discovery. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1579-9_7

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  • DOI: https://doi.org/10.1007/978-1-0716-1579-9_7

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