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Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

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Green Chemistry in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Continuous-flow processing is proving to be an enabling technology for synthetic organic chemists. After an introduction to the advantages and disadvantages of flow processing and an overview of the equipment currently available, the use of flow chemistry in a range of avenues of organic chemistry is showcased. Attention is focused on areas such as hazardous transformations, multistep synthesis, photochemistry, electrochemistry, and organocatalysis. The scope of the chapter is also broadened to techniques used for monitoring flow processes and the incorporation of flow chemistry into the undergraduate teaching laboratory.

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Acknowledgements

The students in our laboratory involved in flow chemistry projects are thanked for their hard work and dedication. Our efforts have been funded by the National Science Foundation (CAREER Award CHE-0847262) and the University of Connecticut. We also thank Vapourtec Ltd. for equipment support as well as input on a number of projects.

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  1. Department of Chemistry, University of Connecticut, Storrs, CT, USA

    Nicholas E. Leadbeater

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  1. World Wide Medicinal Chemistry, Pfizer Inc., San Diego, CA, USA

    Paul F. Richardson

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Leadbeater, N.E. (2022). Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry. In: Richardson, P.F. (eds) Green Chemistry in Drug Discovery. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1579-9_14

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