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Identification and Characterization of Specific Protein–Lipid Interactions Using Molecular Simulation

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Computational Design of Membrane Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2315))

Abstract

Interactions with lipids can dramatically shape and define the activity of membrane proteins. Here, we describe tools that allow the identification of these interactions using molecular dynamics simulation. Additionally, we provide the details of how to use different methods to probe the affinity of these interactions.

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Acknowledgments

The authors thank Drs Anna Duncan, Wanling Song, and Owen Vickery for critical reading and useful discussions.

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Authors and Affiliations

  1. Department of Biochemistry, University of Oxford, Oxford, UK

    Robin A. Corey & Mark S. P. Sansom

  2. School of Life Sciences and Department of Chemistry, University of Warwick, Coventry, UK

    Phillip J. Stansfeld

Authors
  1. Robin A. Corey
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  2. Mark S. P. Sansom
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  3. Phillip J. Stansfeld
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Corresponding author

Correspondence to Robin A. Corey .

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Editors and Affiliations

  1. Department of Life Sciences, University of Coimbra, Coimbra, Portugal

    Irina S. Moreira

  2. BioISI, University of Lisboa, Lisboa, Portugal

    Miguel Machuqueiro

  3. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

    Joana Mourão

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Corey, R.A., Sansom, M.S.P., Stansfeld, P.J. (2021). Identification and Characterization of Specific Protein–Lipid Interactions Using Molecular Simulation. In: Moreira, I.S., Machuqueiro, M., Mourão, J. (eds) Computational Design of Membrane Proteins. Methods in Molecular Biology, vol 2315. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1468-6_8

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  • DOI: https://doi.org/10.1007/978-1-0716-1468-6_8

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1467-9

  • Online ISBN: 978-1-0716-1468-6

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