Abstract
Eosinophils are granulocytes that were historically considered to be terminally differentiated at the time of bone marrow egress. However, more recent evidence provides a new outlook on these cells as complex immunomodulators that are involved in host defense and homeostasis. Our work established a role for eosinophils as mediators of antiviral immune responses during influenza in hosts that were sensitized and challenged with fungal allergens. Herein, we describe methods for working with murine eosinophils in the context of influenza A virus.
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Acknowledgments
This work was supported in part by the American Lung Association Biomedical Grant RG-350980 and the NIH grant R01-AI125481 to AES. Meenakshi Tiwary and Kim S. LeMessurier contributed equally to this work.
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Tiwary, M., LeMessurier, K.S., Samarasinghe, A.E. (2021). Murine Models of Eosinophil Function in Fungal and Viral Infections. In: Walsh, G.M. (eds) Eosinophils. Methods in Molecular Biology, vol 2241. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1095-4_9
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DOI: https://doi.org/10.1007/978-1-0716-1095-4_9
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