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Leukemia Stem Cells pp 3–23Cite as

Introduction and Classification of Leukemias

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Part of the Methods in Molecular Biology book series (MIMB,volume 2185)

Abstract

Classifying the hematological malignancies by assigning cells to their normal counterpart and describing the nature of disease progression are entirely reliant on an accurate picture for the development of the multifarious types of blood and immune cells. In recent years, our understanding of the complex relationships between the various hematopoietic stem cell-derived cell lineages has undergone substantial revision. There has been similar progress in how we describe the nature of the “target” cells that genetic insults transform to give rise to the hematological malignancies. Here I describe how both longstanding and new information has influenced classifying, for diagnosis, the hematological malignancies.

Key words

  • Leukemia
  • Classification
  • Hematopoiesis
  • Stem cells

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Authors and Affiliations

  1. Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Geoffrey Brown

  2. Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Geoffrey Brown

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  1. Geoffrey Brown
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Correspondence to Geoffrey Brown .

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Editors and Affiliations

  1. Immune System Development and Function Unit, Centro de Biologia Molecular "Severo Ochoa", (CSIC/UAM), Madrid, Spain

    César Cobaleda

  2. IBMCC, Laboratory 13, CSIC/Universidad de Salamanca, Salamanca, Spain

    Isidro Sánchez-García

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Brown, G. (2021). Introduction and Classification of Leukemias. In: Cobaleda, C., Sánchez-García, I. (eds) Leukemia Stem Cells. Methods in Molecular Biology, vol 2185. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0810-4_1

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  • DOI: https://doi.org/10.1007/978-1-0716-0810-4_1

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