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Attenuation Methods for Live Vaccines

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Vaccine Delivery Technology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2183))

Abstract

Vaccination was developed by Edward Jenner in 1796. Since then, vaccination and vaccine development research has been a hotspot of research in the scientific community. Various ways of vaccine development are successfully employed in mass production of vaccines. One of the most successful ways to generate vaccines is the method of virulence attenuation in pathogens. The attenuated strains of viruses, bacteria, and parasites are used as vaccines which elicit robust immune response and confers protection against virulent pathogens. This chapter brings together the most common and efficient ways of generating live attenuated vaccine strains in viruses, bacteria, and parasites.

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Author notes

  1. Dipasree Hajra and Akshay Datey contributed equally to this work.

Authors and Affiliations

  1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India

    Dipasree Hajra & Dipshikha Chakravortty

  2. Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India

    Akshay Datey & Dipshikha Chakravortty

Authors
  1. Dipasree Hajra
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  2. Akshay Datey
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  3. Dipshikha Chakravortty
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Corresponding author

Correspondence to Dipshikha Chakravortty .

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Editors and Affiliations

  1. Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA

    Blaine A. Pfeifer

  2. Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA

    Andrew Hill

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Hajra, D., Datey, A., Chakravortty, D. (2021). Attenuation Methods for Live Vaccines. In: Pfeifer, B.A., Hill, A. (eds) Vaccine Delivery Technology. Methods in Molecular Biology, vol 2183. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0795-4_17

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  • DOI: https://doi.org/10.1007/978-1-0716-0795-4_17

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