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Evaluating Zika Virus Pathogenesis in Immunocompromised Mice

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Zika Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2142))

Abstract

Mouse models of Zika virus (ZIKV) infection, which recapitulate certain aspects of ZIKV infection in humans, have demonstrated their utility for studying ZIKV pathogenesis and for the initial screening of antivirals, experimental therapeutics, and candidate vaccines for protective efficacy against ZIKV infection. In this chapter we outline the available mouse models and describe the evaluation of ZIKV pathogenesis in an immunocompromised mouse model of ZIKV infection.

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Authors and Affiliations

  1. Zoonotic Diseases and Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada

    Bryan D. Griffin, David Safronetz & Darwyn Kobasa

  2. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada

    David Safronetz & Darwyn Kobasa

Authors
  1. Bryan D. Griffin
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  2. David Safronetz
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  3. Darwyn Kobasa
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Correspondence to Darwyn Kobasa .

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Editors and Affiliations

  1. CHU de Québec - Université Laval, Centre de Recherche en Infectiologie, Québec, QC, Canada

    Gary Kobinger

  2. CHU de Québec - Université Laval, Québec, QC, Canada

    Trina Racine

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Griffin, B.D., Safronetz, D., Kobasa, D. (2020). Evaluating Zika Virus Pathogenesis in Immunocompromised Mice. In: Kobinger, G., Racine, T. (eds) Zika Virus. Methods in Molecular Biology, vol 2142. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0581-3_3

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  • DOI: https://doi.org/10.1007/978-1-0716-0581-3_3

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0580-6

  • Online ISBN: 978-1-0716-0581-3

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