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Vitamin D and Muscle Sarcopenia in Aging

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Clinical and Preclinical Models for Maximizing Healthspan

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2138))

Abstract

Sarcopenia, the age-dependent decline of muscle mass and performance, is a common condition among elderly population and is related to numerous adverse health outcomes. Due to the effect of sarcopenia on quality of life, disability, and mortality, a greater awareness is important in order to correctly recognize the condition both in community and geriatric settings. Research on sarcopenia prevention and treatment is growing quickly, but many questions are still unanswered. The core of the sarcopenia state includes quantitative and qualitative declines of skeletal muscle. These two aspects should therefore be considered when designing and examining preventive and therapeutic interventions. The role of vitamin D in skeletal muscle metabolism has been highlighted in recent years. The interest arises from the important findings of studies indicating multiple impacts of vitamin D on this tissue, which can be divided into genomic (direct impacts) and non-genomic impacts (indirect impacts). Another important dimension to be considered in the study of vitamin D and muscle fiber metabolism is associated with different expressions of the vitamin D receptor, which differs in muscle tissue, depending on age, gender, and pathology. Vitamin D inadequacy or deficiency is related to muscle fiber atrophy, elevated risk of chronic musculoskeletal pain, sarcopenia, and falls. This review describes the effect of vitamin D in skeletal muscle tissue function and metabolism and includes discussion of possible mechanisms in skeletal muscle.

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Authors and Affiliations

  1. Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Behnaz Abiri

  2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Mohammadreza Vafa

  3. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

    Mohammadreza Vafa

Authors
  1. Behnaz Abiri
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  2. Mohammadreza Vafa
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Correspondence to Mohammadreza Vafa .

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Editors and Affiliations

  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

    Paul C. Guest

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Abiri, B., Vafa, M. (2020). Vitamin D and Muscle Sarcopenia in Aging. In: Guest, P. (eds) Clinical and Preclinical Models for Maximizing Healthspan. Methods in Molecular Biology, vol 2138. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0471-7_2

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  • DOI: https://doi.org/10.1007/978-1-0716-0471-7_2

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0470-0

  • Online ISBN: 978-1-0716-0471-7

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