Stem Cell Tracking with Nanoparticle-Based Ultrasound Contrast Agents
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Cell therapy is revolutionizing modern medicine. To promote this emerging therapy, the ability to image and track therapeutic cells is critical to monitor the progress of the treatment. Ultrasound imaging is promising in tracking therapeutic cells but suffers from poor contrast against local tissues. Therefore, it is critical to increase the ultrasound contrast of therapeutic cells over local tissue at the injection site. Here, we describe a method to increase the ultrasound intensity of therapeutic cells with nanoparticles to make the injected therapeutic cells more visible.
Key wordsCell tracking Ultrasound imaging Contrast agents Nanoparticles Mesenchymal stem cells
This work was supported by NIH (R00 HL117048 and DP2 HL137187) and the American Cancer Society Institutional Research (grant number 14-250-42). F. Chen also acknowledges Eric Zhao for proofreading the chapter.
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