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MAIT Cells in Health and Disease

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MAIT Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2098))

Abstract

Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-related (MR1) molecule. MAIT cells are activated in a MR1-dependent manner in response to microbial-derived riboflavin metabolites which leads to rapid effector functions, but they can also be activated in a MR1-independent manner by cytokines and viruses. The use of mice models and MR1 tetramers, among other recent methodological advances, have provided more insight into the development, mode of activation, characterization in different diseases and tissues of MAIT cells. In this chapter, we provide an overview of MAIT cells and yet remaining questions about their potential therapeutic role.

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Acknowledgments

HK was supported by the Swedish Research Council, the Swedish Childhood Cancer Foundation, the Cancer Society in Stockholm, the Swedish Cancer Foundation, and Karolinska Institutet. MS was supported by Karolinska Institutet and Stockholm County Council. IM was supported by Karolinska Institutet, Clas Groschinskys Minnesfond, and Dr. Ã…ke Olsson Foundation.

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  1. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Isabelle Magalhaes

  2. Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

    Martin Solders & Helen Kaipe

  3. Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden

    Martin Solders & Helen Kaipe

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  1. Isabelle Magalhaes
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  3. Helen Kaipe
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Correspondence to Isabelle Magalhaes .

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  1. Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden

    Helen Kaipe

  2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Isabelle Magalhaes

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Magalhaes, I., Solders, M., Kaipe, H. (2020). MAIT Cells in Health and Disease. In: Kaipe, H., Magalhaes, I. (eds) MAIT Cells. Methods in Molecular Biology, vol 2098. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0207-2_1

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