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Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview

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Neutrophil

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2087))

Abstract

Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak–Higashi Syndrome, neutrophil specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.

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Abbreviations

CGD:

Chronic granulomatous disease

DHR:

Dihydrorhodamine 123

HIES:

Hyperimmunoglobulin E

HSC:

Hematopoietic stem cell

LAD:

Leukocyte adhesion deficiency

LJP:

Localized juvenile periodontitis

MPO:

Myeloperoxidase

NBT:

Nitroblue tetrazolium

phox :

Phagocyte oxidase

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Authors and Affiliations

  1. Department of Pediatrics (Hematology/Oncology), St. Louis Children’s Hospital, Washington University School of Medicine in St. Louis, St. Louis, MO, USA

    Mary C. Dinauer

  2. Department of Pathology and Immunology, St. Louis Children’s Hospital, Washington University School of Medicine in St. Louis , St. Louis, MO, USA

    Mary C. Dinauer

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  1. Mary C. Dinauer
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Correspondence to Mary C. Dinauer .

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Editors and Affiliations

  1. Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA

    Mark T. Quinn

  2. Laboratory of Bacteriology, Rocky Mountain Laboratories Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

    Frank R. DeLeo

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Dinauer, M.C. (2020). Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview. In: Quinn, M., DeLeo, F. (eds) Neutrophil. Methods in Molecular Biology, vol 2087. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0154-9_2

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