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Read-Across for Regulatory Ecotoxicology

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Ecotoxicological QSARs

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Given the magnitude of chemicals that require ecotoxicity assessments for regulatory purposes, read-across allows for the filling in certain data requirements, such as endpoint estimation, screening and prioritization, and hazard identification, provided that they are justified and documented. In this chapter, we present a recompilation of recognized regulations and guidelines, as well as software and tools, used in grouping and read-across for ecotoxicology-related endpoints. Additionally, an exemplary read-across study for the bioconcentration factor prediction is included.

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Abbreviations

ADI:

Applicability domain index

BCF:

Bioconcentration factor

CAS:

Chemical Abstracts Service

ECETOC:

European Centre for Ecotoxicology and Toxicology of Chemicals

ECHA:

European Chemicals Agency

EFSA:

European Food Safety Authority

EU:

European Union

FDA:

Food and Drug Administration

HPV:

High production volume

KNN:

K-nearest neighbor

LOAEL:

Lowest-observed-adverse-effect level

NOAEL:

No-observed-adverse-effect level

NTM:

Non-testing methods

OECD:

Organisation for Economic Co-operation and Development

PBT/vPvB:

Persistent, bioaccumulative, and toxic/very persistent and very bioaccumulative

QSAR:

Quantitative structure-activity relationship

REACH:

Registration, Evaluation, Authorisation and Restriction of Chemicals

US EPA:

United States Environmental Protection Agency

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Department of Toxicology, Yeditepe University, Istanbul, Turkey

    Gulcin Tugcu & Ahmet Aydin

  2. Bogazici University, Institute of Environmental Sciences, Istanbul, Turkey

    Serli Önlü & Melek Türker Saçan

  3. Corporate Product Safety/Henkel AG & Co. KGaA, Düsseldorf, Germany

    Serli Önlü

Authors
  1. Gulcin Tugcu
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  2. Serli Önlü
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  3. Ahmet Aydin
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  4. Melek Türker Saçan
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Corresponding author

Correspondence to Melek Türker Saçan .

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Editors and Affiliations

  1. Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India

    Kunal Roy

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Tugcu, G., Önlü, S., Aydin, A., Saçan, M.T. (2020). Read-Across for Regulatory Ecotoxicology. In: Roy, K. (eds) Ecotoxicological QSARs. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0150-1_13

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  • DOI: https://doi.org/10.1007/978-1-0716-0150-1_13

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0149-5

  • Online ISBN: 978-1-0716-0150-1

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