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eQTL Analysis pp 211-229 | Cite as

Quantitative Trait Loci (QTL) Mapping

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Part of the Methods in Molecular Biology book series (MIMB, volume 2082)

Abstract

Quantitative trait loci (QTL) are genetic regions that influence phenotypic variation of a complex trait, often through genetic interactions with each other and the environment. These are commonly identified through a statistical genetic analysis known as QTL mapping. Here, I present a step-by-step, practical approach to QTL mapping along with a sample data file. I focus on methods commonly used and discoveries that have been made in fishes, and utilize a multiple QTL mapping (MQM) approach in the free software package R/qtl.

Key words

Quantitative trait locus (QTL) Genetic basis Quantitative genetics Epistasis MQM 
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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Biological SciencesClemson UniversityClemsonUSA

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