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The Role of MicroRNAs in Human Diseases

  • Kemal Uğur Tüfekci
  • Meryem Gülfem Öner
  • Ralph Leo Johan Meuwissen
  • Şermin Genç
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1107)

Abstract

About 20 years have passed since the discovery of the first microRNA (miRNA) and by now microRNAs are implicated in a variety of physiological and pathological processes. Since the discovery of the powerful effect miRNAs have on biological processes, it has been suggested that mutations affecting miRNA function may play a role in the pathogenesis of human diseases. Over the past several years microRNAs have been found to play a major role in various human diseases. In addition, many studies aim to apply miRNAs for diagnostic and therapeutic applications in human diseases. In this chapter, we summarize the role of miRNAs in pathological processes and discuss how miRNAs could be used as disease biomarkers.

Keywords

Biomarker Human disease Exosome Mutation Circulating miRNA Single nucleotide polymorphism Copy number variation 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kemal Uğur Tüfekci
    • 1
  • Meryem Gülfem Öner
    • 1
  • Ralph Leo Johan Meuwissen
    • 2
  • Şermin Genç
    • 1
  1. 1.Department of Neuroscience, Institute of Health ScienceUniversity of Dokuz EylulIzmirTurkey
  2. 2.Department of Internal Medicine, School of MedicineUniversity of Dokuz EylulIzmirTurkey

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