Wound Regeneration and Repair pp 265-274

Part of the Methods in Molecular Biology book series (MIMB, volume 1037)

Murine Models of Human Wound Healing

  • Jerry S. Chen
  • Michael T. Longaker
  • Geoffrey C. Gurtner


In vivo wound healing experiments remain the most predictive models for studying human wound healing, allowing an accurate representation of the complete wound healing environment including various cell types, environmental cues, and paracrine interactions. Small animals are economical, easy to maintain, and allow researchers to take advantage of the numerous transgenic strains that have been developed to investigate the specific mechanisms involved in wound healing and regeneration. Here we describe three reproducible murine wound healing models that recapitulate the human wound healing process.

Key words

Wound healing Mouse model Excisional wound Ischemic wound Pressure ulcer 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jerry S. Chen
    • 1
  • Michael T. Longaker
    • 1
    • 2
  • Geoffrey C. Gurtner
    • 2
  1. 1.Department of SurgeryStanford UniversityStanfordUSA
  2. 2.Hagey Laboratory for Pediatric and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative MedicineStanford University School of MedicineStanfordUSA

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