Transgenic Mouse Models

  • Jennifer Skelton
  • Linda H. Gower
  • Anne McGough
  • Patricia A. Labosky
Part of the Methods in Molecular Biology book series (MIMB, volume 1032)


The generation of transgenic mouse models has been a powerful technique for several decades and is still widely used. There have been many manuals and general reviews of this technology. This chapter is designed to be a “how-to” resource with detailed specifics.

Key words

Mice Transgenics Microinjection Pronuclear injection Animal models 


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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Jennifer Skelton
    • 1
  • Linda H. Gower
    • 1
  • Anne McGough
    • 1
  • Patricia A. Labosky
    • 2
  1. 1.Center for Stem Cell BiologyVanderbilt University Medical CenterNashvilleUSA
  2. 2.Office of Strategic Coordination, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the DirectorNIHBethesdaUSA

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