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PharmGKB: The Pharmacogenomics Knowledge Base

  • Caroline F. Thorn
  • Teri E. Klein
  • Russ B. Altman
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1015)

Abstract

The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. The PharmGKB Web site, http://www.pharmgkb.org, displays genotype, molecular, and clinical knowledge integrated into pathway representations and Very Important Pharmacogene (VIP) summaries with links to additional external resources. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.

Key words

PharmGKB Database Pharmacogenetics Pharmacogenomics Genotype Phenotype Pathways VIP genes Pharmacogenes 

Notes

Acknowledgments

The authors would like to acknowledge Dorit Berlin, Michelle Whirl Carrillo, John Conroy, Adrien Coulet, Sean David, Katrina Easton, Ray Fergerson, Yael Garten, Li Gong, Mei Gong, Winston Gor, Joan Hebert, Tina Hernandez-Boussard, Micheal Hewett, Amy Hodge, Laura Hodges, Daniel Holbert, Tiffany Jung, Mark Kiuchi, Steve Lin, Feng Liu, Xing Jian Lou, Charity Lu, Andrew MacBride, Ellen McDonagh, Diane Oliver, Connie Oshiro, Ryan Owen, Daniel Rubin, Katrin Sangkuhl, Farhad Shafa, Ravi Shankar, Rebecca Tang, TC Truong, Ryan Whaley, Mark Woon, and Tina Zhou for their contributions to building the PharmGKB.

The PharmGKB is financially supported by NIH/NIGMS (R24GM61374).

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Caroline F. Thorn
    • 1
  • Teri E. Klein
    • 2
  • Russ B. Altman
    • 1
  1. 1.Department of Genetics, School of MedicineStanford UniversityStanfordUSA
  2. 2.Department of GeneticsStanford University Medical CenterStanfordUSA

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