Pharmacogenomics pp 3-22

Part of the Methods in Molecular Biology book series (MIMB, volume 1015)

Pharmacogenomics: Historical Perspective and Current Status

  • Rosane Charlab
  • Lei Zhang
Protocol

Abstract

Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the interindividual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to tailor drugs to individuals based on their genetic makeup and molecular profile. From early findings in the 1950s uncovering inherited deficiencies in drug metabolism that explained drug-related adverse events, to nowadays genome-wide approaches assessing genetic variation in multiple genes, pharmacogenomics has come a long way. The evolution of pharmacogenomics has paralleled the evolution of genotyping technologies, the completion of the human genome sequencing and the HapMap project. Despite these advances, the implementation of pharmacogenomics in clinical practice has yet been limited. Here we present an overview of the history and current applications of pharmacogenomics in patient selection, dosing, and drug development with illustrative examples of these categories. Some of the challenges in the field and future perspectives are also presented.

Key words

Pharmacogenetics Pharmacogenomics Pharmacokinetics Pharmacodynamics Polymorphism Adverse event Targeted therapy Drug metabolizing enzyme Drug transporter 

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Rosane Charlab
    • 1
  • Lei Zhang
    • 1
  1. 1.Office of Clinical Pharmacology, Office of Translational SciencesCenter for Drug Evaluation and Research, United States Food and Drug AdministrationSilver SpringUSA

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