Thrombin Clotting Time
Thrombin clotting time (TCT) is a coagulation assay used to diagnose congenital and acquired fibrinogen deficiency (Adcock et al., Coagulation handbook, Esoterix Coagulation, Austin, TX, 2002), as well as to identify contamination by heparin, prior to performing additional coagulation assays.
This test is based on the principle that in citrated plasma, the addition of Thrombin allows for formation of a stable clot. The time required for the formation of a stable clot is recorded in seconds and represents the actual TCT result.
Key wordsTCT TT Coagulation test
- 3.Bockenstedt PL (1998) Laboratory methods in hemostasis. In: Loscalzo J, Schafer AI (eds) Thrombosis and hemorrhage, 2nd edn. Williams and Wilkins, Baltimore, pp 517–580Google Scholar
- 6.Chan A, Black L, Ing C, Williams S, Brandao L, Walter K, Abdelhaleem M (2005) Utility of aPTT in monitoring unfractionated heparin in children. J Thromb Haemost 3, abstract OR360.Google Scholar
- 9.Wang JS, Lin C, Karp RB (1994) Comparison of high-dose thrombin time with activated clotting time for monitoring of anticoagulant effects of heparin in cardiac surgical patients. Anaesth Analg 79:9–13Google Scholar
- 16.NCCLS (1998) Collection, transport and processing of blood specimens for coagulation testing and general performance of coagulation assays. In: Standards NCCL (ed) 3rd edn, NCCLS, 940 West Valley Road, Wayne, PA, USA.Google Scholar
- 17.Adcock DM, Jensen R, Johns CS, Macy PA (2002) Coagulation handbook. Esoterix Coagulation, Austin, TXGoogle Scholar