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Experimental Traumatic Spinal Cord Injury

  • Zübeyde Erbayraktar
  • Necati Gökmen
  • Osman Yılmaz
  • Serhat Erbayraktar
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 982)

Abstract

Animal models are important to develope therapies for individuals suffering from spinal cord injuries. For this purpose, rats are commonly preferred. In sharp injury models, spinal cord is completely or incompletely cut to assess axonal regeneration. On the other hand, spinal cord is compressed or contused to mimic the human injury in blunt injury models for understanding as well as managing the secondary pathophysiologic processes following injury. Especially, contusions are thought to be biomechanically similar to vertebral fractures and/or dislocations and thus provide the most realistic experimental setting in which to test potential neuroprotective and regenerative strategies.

Key words

Spinal cord contusion Spinal cord injury Spinal cord transection 

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Zübeyde Erbayraktar
    • 1
  • Necati Gökmen
    • 2
  • Osman Yılmaz
    • 3
  • Serhat Erbayraktar
    • 4
  1. 1.Department of Medical Biochemistry, School of MedicineDokuz Eylul UniversityİnciraltiTurkey
  2. 2.DEpartment of Anesthesia and Reanimation, School of MedicineDokuz Eylul UniversityİnciraltiTurkey
  3. 3.Animal Research Center, School of MedicineDokuz Eylul UniversityİnciraltiTurkey
  4. 4.Department of Neurosurgery, School of MedicineDokuz Eylul UniversityİnciraltiTurkey

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