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Erythropoietin and Engineered Innate Repair Activators

  • Michael Brines
  • Anthony Cerami
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 982)

Abstract

Erythropoietin (EPO) is a pleiotropic type I cytokine that has been identified as a major endogenous tissue protective molecule. In response to injury, EPO and a distinct receptor are expressed with a characteristic temporal and spatial expression pattern. Together, these serve to limit injury and to initiate repair. Administration of EPO in the setting of injury has been shown to be beneficial in a multitude of preclinical models. However, translation into the clinic has been hampered by EPO’s adverse effects, including promotion of thrombosis. Recently, engineered molecules based on EPO’s structure–activity relationships have been developed that are devoid of hematopoietic effects. These compounds are promising candidates for treatment of a wide variety of acute and chronic diseases.

Key words

Innate immune response Inflammation Tissue damage Tissue protection Healing Drug design Type 1 cytokine 

Notes

Disclosure of Interest

The authors are officers of Araim Pharmaceuticals and currently hold stocks/shares in the company.

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Michael Brines
    • 1
  • Anthony Cerami
    • 2
  1. 1.Araim Pharmaceuticals, Inc.OssiningUSA
  2. 2.Araim PharmaceuticalsOssiningUSA

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