Considerations for Sequencing Analyses of Pancreatic Cancer Progression and Metastasis

  • Alvin Makohon-Moore
  • Christine A. Iacobuzio-Donahue
Part of the Methods in Molecular Biology book series (MIMB, volume 980)


Sequencing analyses have been invaluable in identifying the genes associated with pancreatic ­carcinogenesis. However, whereas gene discovery related to carcinogenesis can be fairly straightforward, there are several additional aspects of experimental design that need to be considered when performing genetic analyses of metastatic disease. This chapter aims to review these issues and provide examples of the types of data generated.

Key words

Metastasis Genetics Comparative lesion sequencing Pancreatic cancer 


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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Alvin Makohon-Moore
    • 1
  • Christine A. Iacobuzio-Donahue
    • 1
  1. 1.Department of PathologySol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical InstitutionsBaltimoreUSA

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