Assessing Organismal Aging in the Filamentous Fungus Podospora anserina

Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 965)

Abstract

Podospora anserina is an extensively studied model organism to unravel the mechanism of organismal aging. This filamentous fungus is short-lived and accessible to experimentation. Aging and lifespan are controlled by genetic and environmental traits and, in this model, have a strong mitochondrial etiology. Here, we describe methods and protocols to manipulate and study the aging process in P. anserina at different levels including biochemistry, cell biology, genetics, and physiology.

Key words

Aging Apoptosis Healthspan Lifespan Mitochondrial functions Podospora anserina 

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Copyright information

© Springer Science+Busincess Media, LLC 2013

Authors and Affiliations

  • Heinz D. Osiewacz
    • 1
    • 2
  • Andrea Hamann
    • 1
    • 2
  • Sandra Zintel
    • 1
    • 2
  1. 1.Faculty of Biosciences, Institute of Molecular BiosciencesJohann Wolfgang Goethe University FrankfurtFrankfurtGermany
  2. 2.Frankfurt Cluster of Excellence “Macromolecular Complexes”FrankfurtGermany

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