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Xenotransplantation: An Overview of the Field

  • Veronica Tisato
  • Emanuele CozziEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 885)

Abstract

Xenotransplantation, the transplantation of cells, tissues, or organs between different species, has the potential to overcome the current shortage of human organs and tissues for transplantation. In the last decade, the progress made in the field is remarkable, suggesting that clinical xenotransplantation procedures, particularly those involving cells, may become a reality in the not-too-distant future. However, several hurdles remain, mainly immunological barriers, physiological discrepancies, and safety issues, making xenotransplantion a complex and multidisciplinary discipline.

Key words

Xenotransplantation Transgenic animals Hyperacute rejection Acute humoral xenograft rejection Cellular rejection Cellular transplantation Molecular incompatibility Tolerance Zoonoses 

Notes

Acknowledgments

The authors would like to thank the EU FP6 Integrated Project “Xenome” (www.xenome.eu), contract n° LSHB-CT-2006-037377 and the Consortium for Research in Organ Transplantation (CORIT, Padua, Italy) for their support. Special thanks to Dr. Michela Seveso, Dr. Marta Vadori, and Dr Federica Besenzon for their review of the manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Surgical and Gastroenterological SciencesUniversity of PaduaPaduaItaly
  2. 2.CORIT (Consortium for Research in Organ Transplantation)PaduaItaly
  3. 3.Direzione Sanitaria, Padua General HospitalPaduaItaly

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