Immunogenetics pp 531-547 | Cite as

Donor Registries and Search Strategies

  • Carolyn K. Hurley
  • Machteld Oudshoorn
  • Michelle Setterholm
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 882)

Abstract

The optimal donor of hematopoietic progenitor cells shares alleles of the major histocompatibility genes with the recipient. This chapter describes the strategies aimed at identifying such a matched donor from registries of volunteers or from umbilical cord blood banks.

Key words

Hematopoietic progenitor cell transplantation Histocompatibility Human leukocyte antigen Registries Cord blood banks Unrelated donor search 

References

  1. 1.
    Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354:1813–1826PubMedCrossRefGoogle Scholar
  2. 2.
    Hurley CK et al (2007) Overview of registries, HLA typing and diversity, and search algorithms. Tissue Antigens 69(Suppl 1):3–5PubMedCrossRefGoogle Scholar
  3. 3.
    Foeken LM et al (2010) Monitoring the international use of unrelated donors for transplantation: the WMDA annual reports. Bone Marrow Transplant 45:811–818PubMedCrossRefGoogle Scholar
  4. 4.
    Welte K et al (2010) International exchange of cord blood units: the registry aspects. Bone Marrow Transplant 45:825–831PubMedCrossRefGoogle Scholar
  5. 5.
    Oudshoorn M et al (1994) Bone Marrow Donors Worldwide: a successful exercise in international cooperation. Bone Marrow Transplant 14:3–8PubMedGoogle Scholar
  6. 6.
    Marsh SG et al (2010) Nomenclature for factors of the HLA system, 2010. Tissue Antigens 75:291–455PubMedCrossRefGoogle Scholar
  7. 7.
    Bochtler W et al (2007) World Marrow Donor Association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks. Bone Marrow Transplant 39:737–741PubMedCrossRefGoogle Scholar
  8. 8.
    Robinson J et al (2009) The IMGT/HLA database. Nucleic Acids Res 37:D1013–D1017PubMedCrossRefGoogle Scholar
  9. 9.
    Holdsworth R et al (2009) The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens. Tissue Antigens 73:95–170PubMedCrossRefGoogle Scholar
  10. 10.
    Maiers M, Gragert L, Klitz W (2007) High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol 68:779–788PubMedCrossRefGoogle Scholar
  11. 11.
    Middleton D et al (2003) New allele frequency database. Tissue Antigens 61:403–407. http://www.allelefrequencies.net Google Scholar
  12. 12.
    Solberg OD et al (2008) Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. Hum Immunol 69:443–464PubMedCrossRefGoogle Scholar
  13. 13.
    Lee SJ et al (2007) High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110:4576–4583PubMedCrossRefGoogle Scholar
  14. 14.
    Bray RA et al (2008) National marrow donor program HLA matching guidelines for unrelated adult donor hematopoietic cell transplants. Biol Blood Marrow Transplant 14:45–53PubMedCrossRefGoogle Scholar
  15. 15.
    Schipper RF, D’Amaro J, Oudshoorn M (1996) The probability of finding a suitable related donor for bone marrow transplantation in extended families. Blood 87:800–804PubMedGoogle Scholar
  16. 16.
    Petersdorf EW (2008) Optimal HLA matching in hematopoietic cell transplantation. Curr Opin Immunol 20:588–593PubMedCrossRefGoogle Scholar
  17. 17.
    Shaw BE et al (2010) Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles. Leukemia 24:58–65PubMedCrossRefGoogle Scholar
  18. 18.
    Confer DL et al (2010) Selection of adult unrelated hematopoietic stem cell donors: beyond HLA. Biol Blood Marrow Transplant 16:S8–S11PubMedCrossRefGoogle Scholar
  19. 19.
    Spellman S et al (2010) The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure. Blood 115:2704–2708PubMedCrossRefGoogle Scholar
  20. 20.
    Ottinger HD et al (2002) Positive serum crossmatch as predictor for graft failure in HLA-mismatched allogeneic blood stem cell transplantation. Transplantation 73:1280–1285PubMedCrossRefGoogle Scholar
  21. 21.
    Lau M, Park MS, Terasaki PI (1997) International cell exchange 1974–1996, a 23-year documentation. (eds. Terasaki PI and Gjertson DW. It was published by the UCLA Tissue Typing Laboratory in Los Angeles California) 85–124Google Scholar
  22. 22.
    Noreen HJ et al (2001) Validation of DNA-based HLA-A and HLA-B testing of volunteers for a bone marrow registry through parallel testing with serology. Tissue Antigens 57:221–229PubMedCrossRefGoogle Scholar
  23. 23.
    Xiao Y et al (2009) Evaluating the potential impact of mismatches outside the antigen recognition site in unrelated hematopoietic stem cell transplantation: HLA-DRB1*1454 and DRB1*140101. Tissue Antigens 73:595–598PubMedCrossRefGoogle Scholar
  24. 24.
    Baxter-Lowe LA et al (2009) HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States. Biol Blood Marrow Transplant 15:971–981PubMedCrossRefGoogle Scholar
  25. 25.
    Kawase T et al (2007) High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood 110:2235–2241PubMedCrossRefGoogle Scholar
  26. 26.
    Wade JA et al (2007) HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation. Blood 109:4064–4070PubMedCrossRefGoogle Scholar
  27. 27.
    Duquesnoy R et al (2008) HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors. Biol Blood Marrow Transplant 14:1064–1071PubMedCrossRefGoogle Scholar
  28. 28.
    Spellman S, Klein J, Haagenson M, Askar M, Baxter-Lowe LA, He J, et al (2011) Scoring HLA Class I Mismatches by HistoCheck Does Not Predict Clinical Outcome in Unrelated Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2011 Sep 29PubMedCrossRefGoogle Scholar
  29. 29.
    Kamani N et al (2008) State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants. Biol Blood Marrow Transplant 14:1–6PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Carolyn K. Hurley
    • 1
  • Machteld Oudshoorn
    • 2
    • 3
  • Michelle Setterholm
    • 4
  1. 1.Department of Oncology, CW Bill Young Marrow Donor Recruitment and Research ProgramGeorgetown University Medical CentreWashingtonUSA
  2. 2.Department of Immunohematology and Blood TransfusionLeiden University Medical CentreLeidenThe Netherlands
  3. 3.Europdonor FoundationLeidenThe Netherlands
  4. 4.National Marrow Donor ProgramMinneapolisUSA

Personalised recommendations