Immunogenetics pp 267-277 | Cite as

Impact of HLA Matching and HLA Antibodies in Organ Transplantation: A Collaborative Transplant Study View

  • Caner SüsalEmail author
  • Gerhard Opelz
Part of the Methods in Molecular Biology book series (MIMB, volume 882)


The Collaborative Transplant Study (CTS) was initiated in 1982 in Heidelberg, Germany, and originated from the need to gain further insight into the complex problems and risks involved in human organ transplantation. Currently, more than 400 transplant centers in 45 countries are contributing to this voluntary international effort, and from the beginning of the study, the impact on graft outcome of immunological factors, such as matching for HLA antigens and allosensitization to HLA and non-HLA antigens, have been areas of interest. Herein, we summarize the recent findings from the CTS on these two topics.

Key words

HLA matching HLA antibodies Crossmatch Kidney transplantation Liver transplantation Heart transplantation 



We gratefully acknowledge the generous support of the staff members at participating CTS centers.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Transplantation Immunology, Institute of ImmunologyUniversity of HeidelbergHeidelbergGermany

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