Laser Sintering for the Fabrication of Tissue Engineering Scaffolds

  • Stefan Lohfeld
  • Peter E. McHughEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 868)


Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processed cross section by cross section to create a physical part. In theory, all powdered materials are suitable for sintering; however, only few have been tested successfully. For tissue engineering (TE) applications of this rapid prototyping technology it is an advantage that no toxic solvents or binders are necessary. This chapter reviews the direct and indirect use of LS to fabricate scaffolds for TE from single and multiphase materials.

Key words

Laser sintering Tissue engineering Scaffold Composite materials 


  1. 1.
    Bibb R (2006) Medical modelling. Woodhead Publishing, Cambridge, p 297Google Scholar
  2. 2.
    Huang H et al (2007) Avidin-biotin binding-based cell seeding and perfusion culture of liver-derived cells in a porous scaffold with a three-dimensional interconnected flow-channel network. Biomaterials 28(26):3815–3823CrossRefGoogle Scholar
  3. 3.
    Lohfeld S et al (2006) Manufacturing of small featured PCL scaffolds for bone tissue engineering using selective laser sintering. J Biomech 39(Suppl 1):S216–S212CrossRefGoogle Scholar
  4. 4.
    Smith MH et al (2007) Computed tomography-based tissue-engineered scaffolds in craniomaxillofacial surgery. Int J Med Robot Comput Assist Surg 3(3):207–216CrossRefGoogle Scholar
  5. 5.
    Williams JM et al (2005) Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials 26(23):4817–4827CrossRefGoogle Scholar
  6. 6.
    Wiria FE et al (2007) Poly-[epsilon]-caprolactone/hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering. Acta Biomater 3(1):1–12CrossRefGoogle Scholar
  7. 7.
    Tan KH et al (2003) Scaffold development using selective laser sintering of polyetheretherketone–hydroxyapatite biocomposite blends. Biomaterials 24(18):3115–3123CrossRefGoogle Scholar
  8. 8.
    Antonov EN et al (2005) Three-dimensional bioactive and biodegradable scaffolds fabricated by surface-selective laser sintering. Adv Mater 17(3):327–330CrossRefGoogle Scholar
  9. 9.
    Simpson RL et al (2008) Development of a 95/5 poly(l-lactide-co-glycolide)/hydroxylapatite and beta-tricalcium phosphate scaffold as bone replacement material via selective laser sintering. J Biomed Mater Res B Appl Biomater 84B(1):17–25CrossRefGoogle Scholar
  10. 10.
    Popov VK et al (2007) Laser technologies for fabricating individual implants and matrices for tissue engineering. J Optic Technol 74(9):636–640CrossRefGoogle Scholar
  11. 11.
    Goodridge RD, Dalgarno KW, Wood DJ (2006) Indirect selective laser sintering of an apatite-mullite glass-ceramic for potential use in bone replacement applications. Proc Inst Mech Eng H J Eng Med 220(1):57–68Google Scholar
  12. 12.
    Lin L et al (2007) Design and fabrication of bone tissue engineering scaffolds via rapid prototyping and CAD. J Rare Earths 25(Suppl 2):379–383Google Scholar
  13. 13.
    Hao L et al (2006) Selective laser sintering of hydroxyapatite reinforced polyethylene composites for bioactive implants and tissue scaffold development. Proc Inst Mech Eng H J Eng Med 220(4):521–531CrossRefGoogle Scholar
  14. 14.
    Chua CK et al (2004) Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite biocomposite for craniofacial and joint defects. J Mater Sci Mater Med 15(10):1113–1121CrossRefGoogle Scholar
  15. 15.
    Lee G, Barlow J (1993) Selective laser sintering of bioceramic materials for implants. In: Proceedings of the solid freeform fabrication symposium, Austin, TX, 1993Google Scholar
  16. 16.
    Lee G et al (1996) Biocompatibility of SLS-formed calcium phosphate implants. In: Proceedings of the solid freeform fabrication symposium, Austin, TX, 1996Google Scholar
  17. 17.
    Savalani M et al (2007) Fabrication of porous bioactive structures using the selective laser sintering technique. Proc Inst Mech Eng H J Eng Med 221(8):873–886CrossRefGoogle Scholar
  18. 18.
    Zhang Y et al (2008) Characterization and dynamic mechanical analysis of selective laser sintered hydroxyapatite-filled polymeric composites. J Biomed Mater Res A 86A(3):607–616CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.National Centre for Biomedical Engineering ScienceNational University of Ireland GalwayGalwayIreland
  2. 2.Department of Mechanical and Biomedical EngineeringNational University of Ireland GalwayGalwayIreland

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