Association Mapping and Disease: Evolutionary Perspectives

  • Søren Besenbacher
  • Thomas Mailund
  • Mikkel H. Schierup
Part of the Methods in Molecular Biology book series (MIMB, volume 856)


In this chapter, we give a short introduction to the genetics of complex disease with special emphasis on evolutionary models for disease genes and the effect of different models on the genetic architecture, and finally give a survey of the state-of-the-art of genome-wide association studies.

Key words

Complex diseases Association mapping Genome-wide association studies Common disease/common variant 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Søren Besenbacher
    • 1
    • 2
  • Thomas Mailund
    • 2
  • Mikkel H. Schierup
    • 2
  1. 1.deCODE GeneticsReykjavikIceland
  2. 2.Bioinformatics Research CenterAarhus UniversityAarhusDenmark

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