A Nonlethal Murine Cutaneous Model of Invasive Aspergillosis

  • Ronen Ben-AmiEmail author
  • Dimitrios P. Kontoyiannis
Part of the Methods in Molecular Biology book series (MIMB, volume 845)


Cutaneous models allow researchers to dynamically monitor infection by visually determining changes in skin lesion dimensions over time. We present a nonlethal cutaneous model of invasive aspergillosis (IA) in nude BALB/c mice and describe its use to determine altered virulence in Aspergillus strains and response to antifungal drugs. In addition, as an example of the versatility of this model, we show how the cutaneous model can be used to assess the effect of IA on angiogenesis in vivo.

Key words

Aspergillosis Cutaneous Model Virulence Drug Angiogenesis 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Infectious Disease UnitTel Aviv Sourasky Medical CenterTel AvivIsrael
  2. 2.The University of Texas MD Anderson Cancer CenterHoustonUSA

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