A Nebulized Intra-tracheal Rat Model of Invasive Pulmonary Aspergillosis

  • Guillaume Desoubeaux
  • Jacques ChandenierEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 845)


Animal models are particularly useful for the study of many infectious diseases, including those caused by fungi. Invasive pulmonary aspergillosis is most frequently studied in mouse models. We present here an animal model of this disease based on undernourished immunocompromised rats infected with Aspergillus fumigatus spores by intra-tracheal nebulisation.

Key words

Aspergillosis Animal model Rat Aerosolisation 



We thank J. Montharu for constant and excellent technical assistance.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Parasitologie-Mycologie-Médecine tropicaleCentre Hospitalier Régional et UniversitaireToursFrance

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