Design of Biomolecules for Nanoengineered Biomaterials for Regenerative Medicine

  • Alvaro MataEmail author
  • Liam Palmer
  • Esther Tejeda-Montes
  • Samuel I. Stupp
Part of the Methods in Molecular Biology book series (MIMB, volume 811)


An important goal in the development of highly functional organic materials is to design self-assembling molecules that can reproducibly display chemical signals across length scales. Within the biomedical field, biomolecules are highly attractive candidates to serve as bioactive building blocks for the next generation of biomaterials. The peptide amphiphiles (PAs) developed by the Stupp Laboratory at Northwestern University generated a highly versatile self-assembly code to create well-defined bioactive nanofibers that have been proven to be very effective at signaling cells in vitro and in vivo. Here, we describe the basic steps necessary for synthesis and assembly of PA molecules into functional nanostructures.

Key words

Peptide amphiphiles Peptide synthesis Biomolecules Regenerative medicine Biomaterials 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Alvaro Mata
    • 1
    Email author
  • Liam Palmer
    • 2
  • Esther Tejeda-Montes
    • 1
  • Samuel I. Stupp
    • 3
    • 4
    • 5
  1. 1.The Nanotechnology PlatformParc Científic BarcelonaBarcelonaSpain
  2. 2.Department of ChemistryNorthwestern UniversityEvanstonUSA
  3. 3.Department of ChemistryNorthwestern UniversityEvanstonUSA
  4. 4.Department of Materials Science and EngineeringNorthwestern UniversityEvanstonUSA
  5. 5.Institute for BioNanotechnology in MedicineNorthwestern UniversityEvanstonUSA

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